African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques
نویسندگان
چکیده
منابع مشابه
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head...
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Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain-Barré syndrome and fetal abnormalities, but the underlying mechanisms remain poorly understood. Animal models of infection are thus urgently needed. Here we show that rhesus macaques are susceptible to infection by an Asian-lineage ZIKV closely related to strains currently circulating in the Americas. Following sub...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2021
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02220-20